SML2399

ML327

≥98% (HPLC)

• Sinonimo/i: 1,2-Dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-3-pyridinecarboxamide, CID 60167648
• Formula empirica (notazione di Hill): C₁₉H₁₈N₄O₄
• Numero CAS: 1883510-31-3
• Peso molecolare: 366.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31619239
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [nH]1[c](c(ccc1)C(=O)NCCCNC(=O)c2n[o]c(c2)c3ccccc3)=O
• InChI key: NNNDNXLMQAPQQQ-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

ML327 is a regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.

regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines; inducer of mesenchymal-to-epithelial transition (MET)

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• WGK: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable