SML2234

1S,3R-RSL 3

≥98% (HPLC), powder, GPx4 inhibitor

• Sinonimo/i: RAS-selective lethal, RSL3, (1S, 3R)-2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
• Formula empirica (notazione di Hill): C₂₃H₂₁ClN₂O₅
• Numero CAS: 1219810-16-8
• Peso molecolare: 440.88
• Numero MDL: MFCD30187526
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: 1S,3R-RSL 3, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Stato: powder
• Attività ottica: [α]/D 9.0 to 15.0°, c = 0.5 in methanol
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: ClCC(=O)N1[C@H](Cc2c3c([nH]c2[C@@H]1c4ccc(cc4)C(=O)OC)cccc3)C(=O)OC
• InChI: TXJZRSRTYPUYRW-NQIIRXRSSA-N

Descrizione

Descrizione generale

Ras-selective lethal small molecule 3 (RSL3) induces ferroptosis by inhibiting the activity of glutathione peroxidase 4 (GPx4)[1]. RSL3 not only activates ferroptosis but also blocks the activation of the mammalian target of rapamycin (mTOR) signaling pathway through interactions with GPX4. In thyroid cancer cell lines, RSL3 decreases cell viability, inhibits spheroid formation, and disrupts cell migration in vitro.[2]

Applicazioni

1S,3R-RSL 3 has been used:

• as a glutathione peroxidase 4 (GPX4) inhibitor to study its effects on cell death in subventricular glioblastoma multiforme (GBM) lines[3]
• GPX4 inhibitor and ferroptosis inducer to study its effects on cardiomyocyte death and heart failure in mice[4]
• as a ferroptosis inducer in HT-1080 cellsin cell viability assay[5]

Azioni biochim/fisiol

Ferroptosis inducer; inhibits glutathione peroxidase 4 (GPX4)

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable