SML1885

Mitotane

≥98% (HPLC)

• Sinonimo/i: 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene, 2,4′-DDD, o,p′-DDD
• Formula empirica (notazione di Hill): C₁₄H₁₀Cl₄
• Numero CAS: 53-19-0
• Peso molecolare: 320.04
• UNSPSC Code: 12352200
• NACRES: NA.77
• EC Number: 200-166-6
• MDL number: MFCD00000850
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=C(C(C(Cl)Cl)C2=CC=C(Cl)C=C2)C=CC=C1
• InChI: 1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
• InChI key: JWBOIMRXGHLCPP-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase).

Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane inhibition of SOAT1 in adrenocortical carcinoma cells decreased the formation of cholesteryl esters, which increased free cholesterol levels and caused endoplasmic reticulum (ER) stress, the unfolded protein response, and eventually apoptosis.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Parola di avvertenza: Warning
• Codici di pericolo: H351
• Avvertenze di sicurezza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2
• Classe di stoccaggio: 11 - Combustible Solids
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable