SML1674

UPCDC30245

≥98% (HPLC)

• Sinonimo/i: 1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine
• Formula empirica (notazione di Hill): C₂₈H₃₈FN₅
• Numero CAS: 1883351-01-6
• Peso molecolare: 463.63
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826009
• NACRES: NA.77
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 30 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=CC=C(NC(C2=CC=CC(N3CCC(NCCN4CCN(C(C)C)CC4)CC3)=C2)=C5)C5=C1
• InChI key: LZHXZCVDLATFAR-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC₅₀ value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H315,H319,H335
• Avvertenze di sicurezza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• WGK: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable