SML1664

Deoxynivalenol Ready Made Solution

1 mg/mL

• Sinonimo/i: (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 4-Deoxynivalenol, DON, Dehydronivalenol, RD-toxon, Vomitoxin
• Formula empirica (notazione di Hill): C₁₅H₂₀O₆
• Numero CAS: 51481-10-8
• Peso molecolare: 296.32
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: solution (ethanol: 2-propanol 95:5)
• Storage condition: protect from light

Proprietà

• biological source: Fusarium sp. (Fusarium asiaticum)
• Quality Segment: 200
• form: solution (ethanol: 2-propanol 95:5)
• storage condition: protect from light
• concentration: 1 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O1[C@]2([C@@H]3O[C@H]4[C@@]([C@]2(C[C@H]3O)C)([C@@H](C(=O)C(=C4)C)O)CO)C1
• InChI: 1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
• InChI key: LINOMUASTDIRTM-QGRHZQQGSA-N

Descrizione

Biochem/physiol Actions

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level.

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.

Preparation Note

Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Parola di avvertenza: Danger
• Codici di pericolo: H225,H319
• Avvertenze di sicurezza: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Classe di stoccaggio: 3 - Flammable liquids
• Che succede?: WGK 1
• Punto di infiammabilità (°F): 57.2 °F
• Punto di infiammabilità (°C): 14 °C