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SML1306
S-p-Bromobenzylglutathione cyclopentyl diester
≥98% (HPLC), powder, Glyoxalase 1 inhibitor
Sinonimo/i:
BBGC, BBGD, BrBzGCp2, N-[S-[(4-Bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-Glycine dicyclopentyl ester, S-p-Bromobenzylglutathione dicyclopentyl ester, S-para-Bromobenzylglutathione cyclopentyl diester
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 110.00 |
25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 433.00 CHF 368.05 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C27H38BrN3O6S
Numero CAS:
Peso molecolare:
612.58
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
S-p-Bromobenzylglutathione cyclopentyl diester, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
BrC1=CC=C(CSC[C@H](NC(CC[C@H](N)C(OC2CCCC2)=O)=O)C(NCC(OC3CCCC3)=O)=O)C=C1
InChI
1S/C27H38BrN3O6S/c28-19-11-9-18(10-12-19)16-38-17-23(26(34)30-15-25(33)36-20-5-1-2-6-20)31-24(32)14-13-22(29)27(35)37-21-7-3-4-8-21/h9-12,20-23H,1-8,13-17,29H2,(H,30,34)(H,31,32)/t22-,23-/m0/s1
InChI key
QIFSPGPRHFNZNN-GOTSBHOMSA-N
Application
Biochem/physiol Actions
S-p-Bromobenzylglutathione cyclopentyl diester (BBGC) is a cell-permeable inhibitor of Glyoxalase 1 (GLO1), an enzyme that detoxifies methylglyoxal, a toxic side-product of glycolysis that induces apoptosis at high levels and has been linked to arterial atherogenesis in diabetics. However, tumors use GLO as well and overexpression of GLO1 has been reported in a number of cancers, so GLO1 inhibitors including BBCG have been investigated as possible anticancer agents. Recent studies have indicated that methylglyoxal has some beneficial effects at low levels with GABAA receptor agonist activity, and that GLO1 inhibition with BBGC can reduce anxiety-like behavior and decrease antiseizure activity. S-p-bromobenzylglutathione cyclopentyl diester should be an inportant tool to study the glyoxalase system.
S-p-Bromobenzylglutathione cyclopentyl diester (BBGC) is a cell-permeable inhibitor of Glyoxalase 1 (GLO1).
BBGC possesses antiproliferative activity, observed in human leukemia cells.
Glyoxalases are associated with detoxification process. Inhibition of glyoxalases produces an anti-carcinogenic and anti-inflammatory effect.
Glyoxalases are associated with detoxification process. Inhibition of glyoxalases produces an anti-carcinogenic and anti-inflammatory effect.
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Questo articolo | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay >90% (HPLC) |
| form powder | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: ≥10 mg/mL | solubility water: 50 mg/mL |
| color white to beige | color white to beige | color white to tan | color white |
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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