SML1237

CCT137690

≥98% (HPLC)

• Sinonimo/i: 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine
• Formula empirica (notazione di Hill): C₂₆H₃₁BrN₈O
• Numero CAS: 1095382-05-0
• Peso molecolare: 551.48
• Numero MDL: MFCD18206879
• Codice UNSPSC: 12352200
• ID PubChem: 329825737
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear (warmed)
• Temperatura di conservazione: −20°C
• Stringa SMILE: CN(CC1)CCN1C(C=C2)=CC=C2C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3
• InChI: 1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30); GFLQCBTXTRCREJ-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC₅₀ = 15, 25, and 19 nM for Aurora A, B and C respectively). CCT137690 inhibits tumor growth in amouse xenograft model and causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis in tumor cell lines.

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable