SML1215

Cuspin-1

≥98% (HPLC)

• Sinonimo/i: (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
• Formula empirica (notazione di Hill): C₁₃H₁₀BrNO
• Numero CAS: 337932-29-3
• Peso molecolare: 276.13
• Numero MDL: MFCD00452965
• Codice UNSPSC: 12352200
• ID PubChem: 329825725
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL, clear (warmed)
• Temperatura di conservazione: room temp
• Stringa SMILE: CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
• InChI: 1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3; AJZRSLVRFSCCIL-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.

Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3