SML1083

Ethacrynic acid

≥97% (HPLC), glutathione S-transferase inhibitor, powder

• Sinonimo/i: 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid, ECA, Etacrynic acid, [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid, (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid
• Formula empirica (notazione di Hill): C₁₃H₁₂Cl₂O₄
• Numero CAS: 58-54-8
• Peso molecolare: 303.14
• NACRES: NA.77
• PubChem Substance ID: 329825461
• UNSPSC Code: 12352106
• EC Number: 200-384-1
• MDL number: MFCD00056693
• Assay: ≥97% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: Ethacrynic acid, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
• InChI: 1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• InChI key: AVOLMBLBETYQHX-UHFFFAOYSA-N
• Gene Information: human ... SLC12A1(6557)

Descrizione

Biochem/physiol Actions

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H302
• Avvertenze di sicurezza: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable