SML0922

NSC130813

≥98% (HPLC)

• Sinonimo/i: 4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02
• Formula empirica (notazione di Hill): C₂₆H₂₇ClN₄O₂ · 3HCl
• Numero CAS: 1082532-95-3
• Peso molecolare: 572.35
• NACRES: NA.77
• UNSPSC Code: 51111800
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: −20°C

Descrizione

Biochem/physiol Actions

NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.

NSC130813 is a Xeroderma Pigmentosa Group F (XPF) antagonist, inhibitor of nucleotide excision repair (NER) mechanism.

Other Notes

air sensitive

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable