SML0761

Gossypin

≥90% (HPLC)

• Sinonimo/i: 2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one, 3,3′,4′,5,7,8-Hexahydroxyflavone 8-glucoside, Gossypetin 8-glucoside
• Formula empirica (notazione di Hill): C₂₁H₂₀O₁₃
• Numero CAS: 652-78-8
• Peso molecolare: 480.38
• NACRES: NA.77
• PubChem Substance ID: 329825593
• UNSPSC Code: 12352200
• MDL number: MFCD00017429
• Assay: ≥90% (HPLC)
• Form: powder
• Storage condition: desiccated

Proprietà

• biological source: Hibiscus vitifolius
• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated
• color: , light yellow to dark green-yellow
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
• InChI key: SJRXVLUZMMDCNG-KKPQBLLMSA-N

Descrizione

General description

Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces β-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.

Biochem/physiol Actions

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside that directly binds and inhibits BRAFV600E and CDK4 kinases.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable