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Merck
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Documenti fondamentali

SML0757

Sigma-Aldrich

WS6

≥98% (HPLC)

Sinonimo/i:

4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide, WS-6

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5 MG
CHF 128.00

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CHF 128.00

About This Item

Formula empirica (notazione di Hill):
C29H31F3N6O3
Numero CAS:
1421227-53-3
Peso molecolare:
568.59
Codice UNSPSC:
12352200
NACRES:
NA.77

CHF 128.00

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Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: 20 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

FC(F)(F)c1c(ccc(c1)NC(=O)Cc3ccc(cc3)Oc4ncnc(c4)NC(=O)C5CC5)CN2CCN(CC2)C

InChI

1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)
FTODTDQFHDJWIQ-UHFFFAOYSA-N

Azioni biochim/fisiol

WS6 is an inducer of β cell proliferation, thought to act primarily through modulating the activities of the IKB kinase pathway and ErbB3-binding protein 1 (EBP1) also known as proliferation-associated protein 2G4 (PA2G4), an RNA-binding protein that is involved in growth regulation and inhibition.
WS6 is an inducer of β cell proliferation, thought to act primarily through modulating the activities of the IKB kinase pathway and ErbB3-binding protein 1 (EBP1).
WS6 is an inducer of β cell proliferation, thought to act primarily through modulating the activities of the IKB kinase pathway and ErbB3-binding protein 1 (EBP1). WS6 is also known to stimulate human ɑ cell proliferation. WS6 does not affect β cell differentiation, as no alteration in the number of insulin producing β cells is observed [1]

Caratteristiche e vantaggi

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000245925
0000201259
0000245925
0000201259
0000161291

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WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability.
Boerner B P, et al.
Endocrine Journal, 62(4), 379-386 (2015)
Manuel Garcia-Moreno et al.
Molecular cell, 74(1), 196-211 (2019-02-26)
The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the development of RNA-interactome capture (RIC). However, it remained unknown if the complement of RBPs changes in response to environmental perturbations and whether these rearrangements are important. To answer these

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