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Merck
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Documenti

SML0742

Sigma-Aldrich

EUK-8

≥95% (HPLC)

Sinonimo/i:

(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese, (Salen)manganese(III) chloride, Chloro(bis(salicylidene)ethylenediamine)manganese, Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese, EUK 8, Manganese(salen) chloride

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About This Item

Formula empirica (notazione di Hill):
C16H14ClMnN2O2
Numero CAS:
53177-12-1
Peso molecolare:
356.69
Codice UNSPSC:
12352200
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

, faint to very dark brown

Solubilità

H2O: 1 mg/mL, clear

Temperatura di conservazione

−20°C

InChI

1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3
HBQGFROGWOHBAG-UHFFFAOYSA-K

Azioni biochim/fisiol

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

Altre note

air sensitive

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Yoritada Watanabe et al.
Chemical communications (Cambridge, England), (47)(47), 4958-4960 (2006-12-01)
A new Mn(Salen) complex bearing an ureido group as an auxiliary that is three-dimensionally fixed by a cyclopentane ring fused to the Salen structure was developed. This compound exhibited considerably higher catalase-like activity than the original Mn(Salen), i.e., the cyclopentane-fused
Mitochondrial protection and the reversal of left ventricular remodeling.
Motoaki Sano
Circulation journal : official journal of the Japanese Circulation Society, 73(11), 2017-2018 (2009-10-24)
Rosalind A Rosenthal et al.
Anti-cancer agents in medicinal chemistry, 11(4), 359-372 (2011-04-02)
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are
Filip Matthijssens et al.
Free radical biology & medicine, 45(5), 708-715 (2008-06-25)
Numerous studies have aimed to alleviate oxidative stress in a wide range of organisms by increasing superoxide dismutase (SOD) activity. However, experimental approaches have yielded contradictory evidence, and kinetics models have shown that increases in SOD activity may increase, decrease
Jiquan Zhao et al.
Carbohydrate research, 344(1), 61-66 (2008-11-11)
Several chiral Schiff-base ligands with sugar moieties at C-3 (3') or C-5 (5') of salicylaldehyde were synthesized from reaction of salicylaldehyde derivatives with diamine. These ligands coordinated with Mn(III) to afford the corresponding chiral salen-Mn(III) complexes characterized by FT-IR, MS
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