SML0552

Tirapazamine

≥98% (HPLC), Pro-apoptotic, powder

• Sinonimo/i: 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine, SR 259075, SR 4233, Tirazone, Win 59075
• Formula empirica (notazione di Hill): C₇H₆N₄O₂
• Numero CAS: 27314-97-2
• Peso molecolare: 178.15
• UNSPSC Code: 12352116
• PubChem Substance ID: 329825548
• NACRES: NA.77
• MDL number: MFCD00132954
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: Tirapazamine, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , orange to dark orange-red
• solubility: DMSO: 10 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Nc1n[n+]([O-])c2ccccc2[n+]1[O-]
• InChI: 1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)
• InChI key: ORYDPOVDJJZGHQ-UHFFFAOYSA-N

Descrizione

Application

Tirapazamine has been used to evaluate its cytotoxic effect on U-251 MG (glioblastoma cell line) cell viability.

Biochem/physiol Actions

Under hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.

Under hypoxic conditions, tirapazamine is a potent cytotoxic agent..

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H315,H319,H335
• Avvertenze di sicurezza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable