SML0509

JK-P3

≥98% (HPLC)

• Sinonimo/i: 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
• Formula empirica (notazione di Hill): C₁₈H₁₇N₃O₃
• Numero CAS: 942655-44-9
• Peso molecolare: 323.35
• Numero MDL: MFCD22666405
• Codice UNSPSC: 12352200
• ID PubChem: 329825518
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL (clear solution)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc(cc1OC)C(=O)Nc2cc([nH]n2)-c3ccccc3
• InChI: 1S/C18H17N3O3/c1-23-15-9-8-13(10-16(15)24-2)18(22)19-17-11-14(20-21-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,19,20,21,22); QAZJUVDICQNITG-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

JK-P3 is a VEGFR-2 inhibitor.

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC₅₀ = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable