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SML0410

Sigma-Aldrich

PT-S58

≥98% (HPLC)

Sinonimo/i:

2-Thiophenecarboxylic acid, 3-[[[4-[(1,1-dimethylethyl)amino]-2-methoxyphenyl]amino]sulfonyl]-, methyl ester

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About This Item

Formula empirica (notazione di Hill):
C17H22N2O5S2
Numero CAS:
1356497-92-1
Peso molecolare:
398.50
Numero MDL:
MFCD22666395
Codice UNSPSC:
12352200
ID PubChem:
329825405
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: 10 mg/mL (warmed; clear solution)

Temperatura di conservazione

2-8°C

Stringa SMILE

COC1=CC(NC(C)(C)C)=CC=C1NS(C2=C(C(OC)=O)SC=C2)(=O)=O

InChI

1S/C17H22N2O5S2/c1-17(2,3)18-11-6-7-12(13(10-11)23-4)19-26(21,22)14-8-9-25-15(14)16(20)24-5/h6-10,18-19H,1-5H3
JSUWAIOZKBYWCJ-UHFFFAOYSA-N

Azioni biochim/fisiol

PT-S58 is a PPAR β/δ antagonist.
PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
072M4605V

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Jayant Lohakare et al.
The Journal of dairy research, 85(3), 295-302 (2018-06-27)
The hypothesis of the study was that inhibition of PPARβ/δ increases glucose uptake and lactose synthesis in bovine mammary epithelial cells by reducing the expression of the glucose transporter mRNA destabiliser calreticulin. Three experiments were conducted to test the hypothesis
Lara Costantini et al.
Journal of clinical medicine, 9(8) (2020-08-07)
The treatment of solid cancers with pharmacological all-trans retinoic acid (ATRA) concentrations, even if it is a gold standard therapy for the acute promyelocytic leukaemia (APL), is not always effective due to some resistance mechanisms. Here the resistance to ATRA
Jie Yu et al.
The Journal of clinical endocrinology and metabolism, 105(9) (2020-07-01)
Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In the present study we analyzed the effects of peroxisome-proliferator-activated receptor

Articoli

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Nuclear Receptors (Non-Steroids)

We offer many products related to non-steroid nuclear receptors for your research needs.

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