SML0339

Tideglusib

≥98% (HPLC)

• Sinonimo/i: 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione, NP-12, NP031112
• Formula empirica (notazione di Hill): C₁₉H₁₄N₂O₂S
• Numero CAS: 865854-05-3
• Peso molecolare: 334.39
• Numero MDL: MFCD18633296
• Codice UNSPSC: 12352200
• ID PubChem: 329825344
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: >15 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1SN(C(=O)N1Cc2ccccc2)c3cccc4ccccc34
• InChI: 1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2; PMJIHLSCWIDGMD-UHFFFAOYSA-N
• Informazioni sul gene: human ... GSK3B(2932)

Descrizione

Applicazioni

Tideglusib has been used:

• as a reference compound in ADP-GloTM Kinase assay[1]
• as an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis[2]
• as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells[3]

Azioni biochim/fisiol

Tideglusib is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3).

Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models.

Caratteristiche e vantaggi

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable