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SML0261

Sigma-Aldrich

SC66

≥98% (HPLC)

Sinonimo/i:

(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone

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About This Item

Formula empirica (notazione di Hill):
C18H16N2O
Numero CAS:
871361-88-5
Peso molecolare:
276.33
Numero MDL:
MFCD05025493
Codice UNSPSC:
12352200
ID PubChem:
329825269

Saggio

≥98% (HPLC)

Stato

powder

Colore

faintly yellow to dark yellow

Solubilità

DMSO: ≥5 mg/mL (warmed)

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3

InChI

1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
CYVVJSKZRBZHAV-UNZYHPAISA-N

Azioni biochim/fisiol

SC66 is a dual function Akt inhibitor.
SC66 is an allosteric inhibitor of Akt that prevents binding of PIP3 to the PH domain. The compound prevents activation of Akt by PIP3, and also facilitates ubiquination and degradation of Akt. SC66 inhibition is maintained against a cancer relevant Akt mutation (E17K) that is resistant to the actions of PIP3K inhibitors. SC66 is active in vivo, and significantly inhibits the ability of HEK293T cells to form colonies in soft agar and tumor growth in nude mice.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
022M4608V

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Rong Chen et al.
Oxidative medicine and cellular longevity, 2020, 6954764-6954764 (2020-04-08)
Ischemic postconditioning (IPO) has a strong protective effect against intestinal ischemia-reperfusion (IIR) injury that is partly related to autophagy. However, the precise mechanisms involved are unknown. C57BL/6J mice were subjected to unilateral IIR with or without IPO. After 45 min ischemia
Chao-Yu Loung et al.
Molecules (Basel, Switzerland), 24(18) (2019-09-22)
Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells was determined and compared with the effect of
Yanan Kong et al.
Journal of cellular physiology, 234(11), 20801-20815 (2019-04-30)
In diabetes, the number of bone mesenchymal stem cells (MSCs) decreases and their differentiation is impaired. However, the exact mechanism is unclear. Patients with diabetes often experience sympathetic nerve injury. Norepinephrine (NE), a major mediator of the sympathetic nervous system
Q Lu et al.
Cell death & disease, 6, e2005-e2005 (2015-12-04)
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In
Camilla Olaisen et al.
Cellular signalling, 27(7), 1478-1487 (2015-03-24)
Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cytosolic functions. Many proteins containing one of the two known PCNA-interacting motifs, the
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