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SML0224

Sigma-Aldrich

HI-6

≥98% (HPLC)

Sinonimo/i:

1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride, 4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride, Asoxime chloride, HI 6, HI 6 chloride, HJ 6, Transant

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CHF 110.00
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CHF 442.00

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10 MG
CHF 110.00
50 MG
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About This Item

Formula empirica (notazione di Hill):
C14H16N4O3 · 2Cl
Numero CAS:
34433-31-3
Peso molecolare:
359.21
Numero MDL:
MFCD00869535
Codice UNSPSC:
12352200
ID PubChem:
329825243
NACRES:
NA.77

CHF 110.00

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Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

H2O: 15 mg/mL (clear solution)

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1

InChI

1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H
QELSIJXWEROXOE-UHFFFAOYSA-N

Descrizione generale

HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.[1]

Azioni biochim/fisiol

HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.
HI-6 is an efficient oxime cholinesterase reactivator.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
106M4728V
096M4706V
105M4736V
035M4790V
015M4720V

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Paul M Lundy et al.
Toxicology, 285(3), 90-96 (2011-04-29)
The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical warfare (CW) organophosphorous (OP) nerve agent poisoning. While they are effective against several of the identified threat CW
C G Rousseaux et al.
Canadian journal of physiology and pharmacology, 67(10), 1183-1189 (1989-10-01)
HI-6 is an oxime experimentally developed for reactivation of previously untreatable soman-phosphorylated acetylcholinesterase. It has been shown to be effective in restoring acetylcholinesterase activity after poisoning with other "nerve agents" namely VX and sarin; however, its antidotal qualities for the
Miroslav Pohanka et al.
Environmental toxicology and pharmacology, 32(1), 75-81 (2011-07-27)
Asoxime (HI-6) is a well known oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited even by sarin or soman. The present experiment was aimed to determine markers of oxidative stress represented
Helen Mumford et al.
Chemico-biological interactions, 203(1), 160-166 (2012-09-18)
Potent organophosphorous (OP) agents, such as VX, are hazardous by absorption through the skin and are resistant to conventional pharmacological antidotal treatments. The residence time of a stoichiometric bioscavenger, human butyrylcholinesterase (huBuChE), in the plasma more closely matches that of
T Seeger et al.
Toxicology letters, 206(1), 72-76 (2011-08-02)
An important factor for successful therapy of poisoning with organophosphorus compounds (OP) is the rapid restoration of blocked respiratory muscle function. To achieve this goal, oximes are administered for reactivation of inhibited acetylcholinesterase (AChE). Unfortunately, clinically used oximes, e.g. obidoxime
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