SML0187

CJ-13610

≥98% (HPLC)

• Sinonimo/i: Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
• Formula empirica (notazione di Hill): C₂₂H₂₃N₃O₂S
• Numero CAS: 179420-17-8
• Peso molecolare: 393.50
• NACRES: NA.77
• PubChem Substance ID: 329825216
• UNSPSC Code: 51111800
• MDL number: MFCD00948114
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
• InChI: 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
• InChI key: VPTONMHDLLMOOV-UHFFFAOYSA-N

Descrizione

Application

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Biochem/physiol Actions

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

Potent 5-lipoxygenase inhibitor

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.

Features and Benefits

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable