Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

SML0177

Sigma-Aldrich

AUDA

≥98% (HPLC)

Sinonimo/i:

12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali

Scegli un formato

10 MG
CHF 88.10
50 MG
CHF 342.00

CHF 88.10

Check Cart for Availability
Richiedi un ordine bulk
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
10 MG
CHF 88.10
50 MG
CHF 342.00

About This Item

Formula empirica (notazione di Hill):
C23H40N2O3
Numero CAS:
479413-70-2
Peso molecolare:
392.58
Numero MDL:
MFCD12912267
Codice UNSPSC:
12352200
ID PubChem:
329825206
NACRES:
NA.77

CHF 88.10

Check Cart for Availability
Richiedi un ordine bulk

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: ≥10 mg/mL at warmed to 60 °C

Temperatura di conservazione

−20°C

Stringa SMILE

OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2

InChI

1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23-
XLGSEOAVLVTJDH-UKBVAGSOSA-N

Applicazioni

AUDA has been used in the inhibition of epoxide hydrolase in human macrophages[1] and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.[2]
AUDA may be used in soluble epoxide hydrolase-mediated cell signaling studies.

Azioni biochim/fisiol

AUDA is a potent inhibitor of soluble epoxide hydrolase
Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension.[3] AUDA also renders protection against myocardial ischemia-reperfusion injury[4] and cerebral ischemia.[5]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000191891
0000191892
0000191892
0000191891
0000068305

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

In Sook Cho et al.
Molecules (Basel, Switzerland), 25(18) (2020-09-26)
Flavonoids and triterpenoids were revealed to be the potential inhibitors on soluble epoxide hydrolase (sEH). The aim of this study is to reveal sEH inhibitors from Fuji apples. A flavonoid and three triterpenoids derived from the fruit of Malus domestica
Jang Hoon Kim et al.
Biomolecules, 10(2) (2020-01-30)
: Three flavonoids derived from the leaves of Capsicum chinense Jacq. were identified as chrysoeriol (1), luteolin-7-O-glucopyranoside (2), and isorhamnetin-7-O-glucopyranoside (3). They had IC50 values of 11.6±2.9, 14.4±1.5, and 42.7±3.5 µg/mL against soluble epoxide hydrolase (sEH), respectively. The three inhibitors
Jung Pyo Lee et al.
PloS one, 7(5), e37075-e37075 (2012-05-17)
Soluble epoxide hydrolase (sEH) in endothelial cells determines the plasma concentrations of epoxyeicosatrienoic acids (EETs), which may act as vasoactive agents to control vascular tone. We hypothesized that the regulation of sEH activity may have a therapeutic value in preventing
PD n-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function
Pistorius K, et al.
Cell Chemical Biology, 25(6), 749-760 (2018)
Alexis N Simpkins et al.
The American journal of pathology, 174(6), 2086-2095 (2009-05-14)
Inhibition of soluble epoxide hydrolase (SEH), the enzyme responsible for degradation of vasoactive epoxides, protects against cerebral ischemia in rats. However, the molecular and biological mechanisms that confer protection in normotension and hypertension remain unclear. Here we show that 6
Visualizza tutti i documenti correlati

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.