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Merck
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Documenti

SCP0200

Sigma-Aldrich

Neuromedin N

Sinonimo/i:

NMN-125, NN, NT/N, NmN

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About This Item

Formula empirica (notazione di Hill):
C38H63N7O8
Peso molecolare:
745.95
Codice UNSPSC:
12352200
NACRES:
NA.32

Saggio

≥95% (HPLC)

Forma fisica

lyophilized

Composizione

Peptide Content, ≥65%

Condizioni di stoccaggio

protect from light

N° accesso UniProt

P30990

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... NTS(4922)

Amino Acid Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Azioni biochim/fisiol

Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model.
Wakabayashi-Nakao K
Oncology Reports, 28(4), 1181-1186 (2012)
M De la Fuente et al.
Journal of neuroimmunology, 42(1), 97-104 (1993-01-01)
The neuropeptides neurotensin and neuromedin N (from 10(-12) M to 10(-9) M) have been shown in this study to stimulate significantly in vitro several steps of the phagocytic process: adherence to substrate, chemotaxis, ingestion of inert particles (latex beads) and
L K Malendowicz et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 47(1), 41-45 (1995-01-01)
The effects of a subcutaneous bolus injection of 2 micrograms neurotensin (NT) or neuromedin N (NMN) on the function of the hypothalamo-pituitary-adrenocortical axis were investigated in both normal and cold-stressed rats. The blood concentrations of ACTH, corticosterone (B) and aldosterone
E B Binder et al.
Pharmacological reviews, 53(4), 453-486 (2001-12-06)
Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential
J J Garrido et al.
Regulatory peptides, 41(1), 27-37 (1992-09-03)
The action of neurotensin and related peptides has not been yet studied on lymphocytes, although there are studies indicating the stimulative action of neurotensin, a peptide first isolated from bovine hypothalamus, on different functions of phagocytic immune cells. The present
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