Solutions prepared at 1 mg/ml may be stored up to 8 weeks at 2 - 8°C or 20°C. This material decomposes rapidly in acidic or alkaline conditions. Solutions are most stable when prepared in degassed water and at neutral pH. Avoid repeated freeze/thaw cycles.
SBR00067
Rifampicin Water Soluble
solubility: 50 mg/mL in water, freely soluble
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About This Item
Codice UNSPSC:
51283601
NACRES:
NA.76
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Stato
solid
Livello qualitativo
Attività specifica
(Antibacterial)
Solubilità
water: freely soluble 50 mg/mL
Spettro attività antibiotica
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses
Modalità d’azione
protein synthesis | interferes
Temperatura di conservazione
−20°C
Descrizione generale
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.[1] Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).[2] Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.[3] In addition, Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.[4]
Applicazioni
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Azioni biochim/fisiol
Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles.
Peyret, Hadrien, et al
Recombinant proteins from plants: production and isolation of clinically useful compounds, 103-111 (2022)
Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)
Tomohiro Umeda et al.
Biomedicines, 10(2), 297-297 (2022-02-26)
The cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in Alzheimer's disease (AD) and other tauopathies. Recent studies suggest that tau oligomers, rather than fibrils, participate in this process. We previously showed
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SBR00067-- I plan to dissolve in water and aliquot in 1 ml amounts. At what temperature should the aliquotes be stored and upto how long it can be stored ( e- -20 C/-70C) After dissolving in water, how long the solution can be stored at -20 C
1 answer-
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