SAB5701913

Anti-Phospho-CRK/CRKII-Y221 antibody produced in rabbit

• Codice UNSPSC: 12352203
• NACRES: NA.43

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: monoclonal
• Forma fisica: liquid
• Reattività contro le specie: rat, human
• Concentrazione: 0.53 mg/mL
• tecniche: western blot: 1:500-1:2000
• N° accesso UniProt: P46108
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pTyr221)
• Informazioni sul gene: human ... CRK(1398)

Descrizione

Descrizione generale

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Immunogeno

A phospho specific peptide corresponding to residues surrounding Y221 of human CRK/CRKII

Stato fisico

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable