SAB5700728

Anti-CASC5 antibody produced in rabbit

• Sinonimo/i: AF15Q14, CASC5, CT29, D40, KNL1, MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: 195; 205; 262; 265
• Reattività contro le specie: human, rat
• Concentrazione: 3.01 mg/ml
• tecniche: immunofluorescence: 1:50-1:100; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:2000
• N° accesso UniProt: Q8NG31
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CASC5(57082)

Descrizione

Descrizione generale

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

Immunogeno

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3).

Stato fisico

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stoccaggio e stabilità

Store at -20℃. Avoid freeze / thaw cycles.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable