SAB4501954
Anti-HNRNP M antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
HNRPM, heterogeneous nuclear ribonucleoprotein M
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
antigen 77 kDa
Reattività contro le specie
human, rat, mouse
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... HNRNPM(4670)
Descrizione generale
Anti-HNRNP M Antibody detects endogenous levels of total HNRNP M protein.
HNRNP M (heterogeneous nuclear ribonucleoprotein M) gene is mapped to human chromosome 19p13.2. It codes for a nucleocytoplasmic shuttling RNA binding protein.
Immunogeno
The antiserum was produced against synthesized peptide derived from human hnRNP M.
Immunogen Range: 11-60
Immunogen Range: 11-60
Azioni biochim/fisiol
HnRNP M (heterogeneous nuclear ribonucleoprotein M) is an RNA binding protein and participates in mRNA splicing mechanism. It is significantly involved in the formation of mature mRNAs from heterogeneous nuclear RNAs. The encoded protein acts as an important gene expression regulating factor. HnRNPM is involved in the activation of IRES (internal ribosomal entry site)-dependent translation of FGF1 (fibroblast growth factor 1). Thus, this protein is associated with myoblast differentiation. HNRNP M expression is associated with the invasion and metastasis events of tumor cells. Upregulation of HNRNP M is observed in breast cancer and human colorectal epithelial carcinogenesis. Therefore, HnRNP M may serve as an important biomarker for cancer.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Shuijiao Chen et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(5), G394-G403 (2014-01-02)
Colorectal carcinoma (CRC) is one of the most common cancers in the world, and identification of new CRC biomarkers will be helpful for the diagnosis and treatment of CRC. For isobaric tags for relative and absolute quantitation (iTRAQ) analysis, fresh
Huizhi Sun et al.
Genes, chromosomes & cancer, 56(8), 598-607 (2017-04-11)
HnRNPM is an essential splicing factor and its expression is closely correlated with invasion and metastasis of tumor cells. The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and CD44 splice variants have been implicated in specific
Jacqueline Smith et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 13(6), 310-315 (2002-07-13)
Human Chromosome 19 (HSA19) is virtually completely sequenced. A complete physical contig map made up of BACs and cosmids is also available for this chromosome. It is, therefore, a rich source of information that we have used as the basis
Julienne M Jagdeo et al.
Journal of virology, 89(14), 7064-7078 (2015-05-01)
Picornavirus infection involves a dynamic interplay of host and viral protein interactions that modulates cellular processes to facilitate virus infection and evade host antiviral defenses. Here, using a proteomics-based approach known as TAILS to identify protease-generated neo-N-terminal peptides, we identify
Nadera Ainaoui et al.
PloS one, 10(9), e0136466-e0136466 (2015-09-04)
Fibroblast growth factor 1 (FGF1) is induced during myoblast differentiation at both transcriptional and translational levels. Here, we identify hnRNPM and p54nrb/NONO present in protein complexes bound to the FGF1 promoter and to the mRNA internal ribosome entry site (IRES).
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