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SAB4501536

Sigma-Aldrich

Anti-IKK-β antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

I-κ-B kinase 2, I-κ-B-kinase β, IKK-β, IKK-B, IKK2

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About This Item

Numero MDL:
MFCD02263521
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 86 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunohistochemistry: 1:50-1:100

N° accesso NCBI

O14920

N° accesso UniProt

O14920

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IKBKB(3551)

Descrizione generale

IKBKB codes for the enzyme, inhibitor of nuclear factor kappa B kinase subunit β (IKK-β/I-K-B kinase 2). It is mapped to human chromosome 8p11.

Immunogeno

The antiserum was produced against synthesized peptide derived from human IKK-beta.

Immunogen Range: 166-215

Applicazioni

Anti-IKK-β antibody produced in rabbit has been used in western blotting.

Azioni biochim/fisiol

Inhibitor of nuclear factor kappa B kinase subunit β (IKK-β) acts as a regulator of cell survival and inflammatory response. It promotes cell survival and metabolic adaptation during glutamine deprivation. IKK-β phosphorylates inhibitor of KB proteins and facilitates their degradation. This further leads to the activation of nuclear factor KB (NF-KB) transcription factors. It also phosphorylates β-catenin, tuberous sclerosis 1 (TSC1) and Bcl-2-associated death promoter (BAD).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor-KB ligand-induced nuclear factor-KB activation in glucocorticoid-induced osteoporosis.
Liu Y, et al.
Experimental and Therapeutic Medicine, 14(5), 4009-4016 (2017)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Michael A. R, et al.
Genes & Development, 30(16), 1837- 1851 (2016)
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al.
The New England Journal of Medicine, 369(26), 2504-2514 (2013)
Canonical nuclear factor KB pathway links tumorigenesis of synchronous mantle-cell lymphoma, clear-cell renal-cell carcinoma, and GI stromal tumor.
Guo R, et al.
Journal of Clinical Oncology, 29(10), e257-e261 (2011)
Yuanxin Liu et al.
Experimental and therapeutic medicine, 14(5), 4009-4016 (2017-10-27)
The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.