SAB4501319

Anti-GRM2 antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: GPRC1B, GRM2, MGLUR2, Metabotropic glutamate receptor 2, mGluR2
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: antigen 95 kDa
• Reattività contro le specie: rat, human, mouse
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:1000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• N° accesso NCBI: Q14416
• N° accesso UniProt: Q14416
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... GRM2(2912)

Descrizione

Descrizione generale

Anti-GRM2 Antibody detects endogenous levels of total GRM2 protein.

Metabotropic glutamate receptor 2 (MGLUR2/GRM2) with 872 amino acids, is encoded by the gene mapped to human chromosome 3. GRM2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. GRM2 is characterized with an α-helical helix 8 (H8) domain.

Immunogeno

The antiserum was produced against synthesized peptide derived from human GRM2.

Immunogen Range: 241-290

Azioni biochim/fisiol

Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. GRM2 signaling inhibits adenylyl cyclase (AC) activity. GRM2 is required for the modulation of synaptic transmission.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable