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SAB4500395

Sigma-Aldrich

Anti-Collagen XII α1 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

COCA1, Collagen α-1(XII) chain

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 333 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

N° accesso NCBI

Q99715

N° accesso UniProt

Q99715

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... COL12A1(1303)

Descrizione generale

Anti-Collagen XII α1 Antibody detects endogenous levels of total Collagen XII α1 protein.
Collagen XII α1 belongs to the FACIT collagens (fibril-associated collagens with interrupted triple helices) family. It codes for the alpha chain of type XII collagen. It is located on human chromosome 6q13.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Collagen XII alpha1.

Immunogen Range: 1481-1530

Applicazioni

Anti-Collagen XII α1 antibody has been used in immunohistochemistry.

Azioni biochim/fisiol

Collagen XII α1 participates in a benign bone tumor, subungual exostosis. Collagen XII organize the collagen fibrils and thereby preserves the bone and muscle integrity. Mutations in collagen XII results in Ehlers–Danlos/myopathy overlap syndrome.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy.
Hicks D, et al.
Human Molecular Genetics, 23(9), 2353-2363 (2013)
Collagen XII: protecting bone and muscle integrity by organizing collagen fibrils.
Chiquet M, et al.
The International Journal of Biochemistry & Cell Biology, 53, 51-54 (2014)
Ivana Zvackova et al.
Frontiers in physiology, 8, 554-554 (2017-08-22)
Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small
Taketoshi Yasuda et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(11), 1499-1506 (2009-08-04)
Chondromyxoid fibroma, a rare benign bone tumor, may be mistaken for chondrosarcoma. Although cytogenetic studies of chondromyxoid fibroma are few, rearrangements of the long arm of chromosome 6, frequently expressed as an inv(6)(p25q13), are prominent. In this study, conventional cytogenetic

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