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Merck
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Key Documents

SAB4300427

Sigma-Aldrich

Anti-PAK1 (Ab-212) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-MGC130000 antibody produced in rabbit, Anti-MGC130001 antibody produced in rabbit, Anti-PAKalpha antibody produced in rabbit, Anti-p21 protein (Cdc42 / Rac)-activated kinase 1 antibody produced in rabbit

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About This Item

Numero MDL:
MFCD03457569
Codice UNSPSC:
12352203

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

~68 kDa

Reattività contro le specie

human, mouse, rat

Concentrazione

1 mg/mL

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotipo

IgG

Sequenza immunogenica

(P-V-T-P-T)

N° accesso NCBI

NP_001122092.1

N° accesso UniProt

Q13153

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... PAK1(5058)

Immunogeno

Peptide sequence around aa. 210-214 (P-V-T-P-T), according to the protein PAK1.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Fariborz Mortazavi et al.
BMC cancer, 15, 381-381 (2015-05-10)
Key effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC). We used NSCLC clinical specimens to
Matthew Rettig et al.
PloS one, 7(7), e42012-e42012 (2012-08-01)
The role of c-Crk (CRK) in promoting metastasis is well described however the role of CRK phosphorylation and the corresponding signaling events are not well explained. We have observed CRK-II serine 41 phosphorylation is inversely correlated with p120-catenin and E-cadherin
Gholam H Pezeshkpour et al.
Genes & cancer, 4(7-8), 315-324 (2013-10-30)
CRK (c-Crk) as an adaptor protein is involved in several oncogenic signal transduction pathways, conveying oncogenic signals to its downstream effectors and thereby affecting multiple cellular processes including proliferation, differentiation, and migration. For example, we have observed that CRK expression

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