SAB4200439

Anti-EXOSC5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinonimo/i: Anti-Exosome component 5, p12B, Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-hRrp46p
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: antigen ~25 kDa
• Reattività contro le specie: human
• Concentrazione: ~1.0 mg/mL
• tecniche: immunoprecipitation (IP): 1-2 μg using lysates of human HeLa cells.; indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 1-2 μg/mL using whole extracts of human HEK-293T cells.
• N° accesso UniProt: Q9NQT4
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... EXOSC5(56915)

Descrizione

Descrizione generale

Exosome component 5 (EXOSC5) protein is a non-catalytic element of the RNA exosome complex in eukaryotes. The EXOSC5 gene is located on the human chromosome at 19q13.2.

Specificità

Anti-EXOSC5 (N-terminal) recognizes human EXOSC5.

Immunogeno

peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.

Applicazioni

Anti-EXOSC5 (N-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Azioni biochim/fisiol

Exosome component 5 (EXOSC5) plays a role in the processing and degradation of RNA. This protein also plays a role in cleaving the DNA during apoptosis. EXOSC5 possesses a 3′-5′ exoribonuclease activity. Overexpression of the EXOSC5 gene is associated with several cancers such as melanoma, prostate, colorectal and lung cancer.

Stato fisico

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Stoccaggio e stabilità

For continuous use, store at 2-8°C for up to one month. Forextended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable