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SAB4200328

Sigma-Aldrich

Anti-acetyl-Histone H3 [Ac-Lys56]

IgG fraction of antiserum

Sinonimo/i:

Anti-H3.4, Anti-H3/g, Anti-H3FT, Anti-H3K56ac, Anti-H3t, Anti-HIST3H3

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About This Item

Codice UNSPSC:
12352203

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~15 kDa

Reattività contro le specie

rat, human, mouse

tecniche

western blot: 1:1000-1:2000 using NIH3T3 or HeLa cell lysates

N° accesso UniProt

Q16695

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

acetylation (Lys56)

Informazioni sul gene

human ... HIST3H3(8290)

Descrizione generale

Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).

Immunogeno

synthetic peptide containing acetylated Lys56 of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.

Applicazioni

Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.

Azioni biochim/fisiol

Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Xie W, et al.
Molecular Cell, 33(4), 417-427 (2009)
A solitary human H3 histone gene on chromosome 1
Albig W, et al.
Human Genetics, 97(4), 486-491 (1996)
Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae
Azad GK, et al.
PLoS ONE, 8(3), e59003-e59003 (2013)
Histone Variants: Signaling or Structural Modules
Handbook of Cell Signaling, 2409-2425 (2010)
Shraddha Chauhan et al.
Environmental science and pollution research international, 31(20), 30149-30162 (2024-04-11)
Nanoparticles, particularly magnesium oxide nanoparticles (MgO-NPs), are increasingly utilized in various fields, yet their potential impact on cellular systems remains a topic of concern. This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae
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