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Merck
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SAB4200175

Sigma-Aldrich

Anti-Atg101 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Sinonimo/i:

Anti-Atg13-interacting protein, Anti-C12orf44, Anti-autophagy-related protein 101, Anti-chromosome 12 open reading frame 44

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

~30 kDa

Reattività contro le specie

human

Concentrazione

~1.0 mg/mL

tecniche

western blot: 0.25-0.5 μg/mL using whole extracts of HEK-293T cells over expressing human Atg101

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... C12orf44(60673)

Categorie correlate

Descrizione generale

Autophagy101 (Atg101) is located on the human chromosome at 12q13.13.

Applicazioni

Anti-Atg101 antibody has been used in
  • immunoblotting
  • immunofluorescence
  • immunopurification

Azioni biochim/fisiol

Autophagy101 (Atg101) is a mammalian Autophagy13 (Atg13) binding protein essential for autophagy. Atg13 forms a stable complex with ULK1 (Serine/threonine-protein kinase ULK1) and FIP200 (FAK family kinase-interacting protein of 200 kDa). Atg101 associates with the ULK1-Atg13- FIP200 complex through direct interaction with Atg13. Mammalian target of rapamycin (mTOR) interacts with the ULK1-Atg13-FIP200 complex in a nutrient dependent manner, suggesting that mTOR regulates autophagy through this complex.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Mei Yang et al.
Science advances, 2(9), e1601167-e1601167 (2016-09-13)
The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) is a
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Hieke N, et al.
Autophagy, 11(9), 1471-1483 (2015)
Systematic analysis of ATG13 domain requirements for autophagy induction
Wallot-Hieke N, et al.
Autophagy, 14(5), 743-763 (2018)
Molecular Machinery and Genetics of the Autophagy Pathway
Autophagy in health and disease, 16-16 (2012)
Stefan Drießen et al.
Autophagy, 11(9), 1458-1470 (2015-07-25)
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex consisting of the serine/threonine protein kinase ULK1
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