SAB3500122
Monoclonal Anti-PD-1 antibody produced in mouse
clone 7A11B1, purified immunoglobulin, buffered aqueous solution
Sinonimo/i:
Anti-CD279, Anti-PDCD-1, Anti-Programmed cell death 1
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100 μG
CHF 431.00
CHF 431.00
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Per il tuo target è disponibile un anticorpo ricombinante privo di conservanti. Prova ZRB1025
Scegli un formato
Cambia visualizzazione
100 μG
CHF 431.00
About This Item
CHF 431.00
Check Cart for Availability
Per il tuo target è disponibile un anticorpo ricombinante privo di conservanti. Prova ZRB1025
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
7A11B1, monoclonal
Stato
buffered aqueous solution
Reattività contro le specie
mouse, human, rat
tecniche
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... PDCD1(5133)
Descrizione generale
Programmed cell death 1 protein (PDCD1) is mapped to human chromosome 2q37.3. PDCD1 belongs to the Cluster of Differentiation 28 (CD28) family of receptors and has an immunoinhibitory domain. It is expressed in T and B lymphocytes.
Immunogeno
raised against an ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.
Azioni biochim/fisiol
Programmed cell death 1 protein (PDCD1) modulates lymphocyte activation. Single nucleotide polymorphisms in PDCD1 is implicated in systemic lupus erythematosus, an autoimmune inflammatory disease.
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Descrizione del bersaglio
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Stato fisico
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
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Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects
Ferreiros-Vidal I, et al.
Arthritis and Rheumatism, 50(8), 2590-2597 (2004)
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.
Prokunina L
Nature Genetics, 32(4), 666-669 (2002)
Nicole A Braun et al.
American journal of respiratory and critical care medicine, 190(5), 560-571 (2014-07-30)
Effective therapeutic interventions for chronic, idiopathic lung diseases remain elusive. Normalized T-cell function is an important contributor to spontaneous resolution of pulmonary sarcoidosis. Up-regulation of inhibitor receptors, such as programmed death-1 (PD-1) and its ligand, PD-L1, are important inhibitors of
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