S8939

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

• Numero MDL: MFCD03458482
• Codice UNSPSC: 51111800
• NACRES: NA.32

Proprietà

• Ricombinante: expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
• Livello qualitativo: 200
• Forma fisica: buffered aqueous solution
• PM: ~48 kDa by SDS-PAGE
• N° accesso UniProt: O00141
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... SGK1(6446)

Descrizione

Descrizione generale

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

Azioni biochim/fisiol

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.

Kinase assays.

Definizione di unità

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

Stato fisico

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

Note legali

Brij is a registered trademark of Croda International PLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids