S8633
Sphingomyelinase from Staphylococcus aureus
buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry)
Sinonimo/i:
Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
25 units | Per conoscere la disponibilità, visualizza il carrello | CHF 238.00 |
50 units | Per conoscere la disponibilità, visualizza il carrello | CHF 409.00 |
Informazioni su questo articolo
Numero CAS:
UNSPSC Code:
12352204
NACRES:
NA.32
MDL number:
Specific activity:
100-300 units/mg protein (Lowry)
Servizio Tecnico
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Permettici di aiutartiform
buffered aqueous glycerol solution
Quality Segment
specific activity
100-300 units/mg protein (Lowry)
storage temp.
2-8°C
Application
Sphingomyelinase from Staphylococcus aureus has been used to:
- induce neurotoxicity in rat cortical cultures to study the protective effects of minocycline[1]
- determine the concentration of sphingomyelin from serum samples[2]
- enhance sphingomyelinase activity to study PARK9-mediated exosome biogenesis[3]
Biochem/physiol Actions
Bacterial sphingomyelinase is active at neutral pH. When used in cell culture in vitro, it hydrolyzes the sphingomyelin on the outer leaflet of the plasma membrane and produces ceramide that is lipid-soluble. Sphingomyelinase is the key enzyme in the sphingomyelinase/ceramide pathway, which is implicated in the pathogenesis of several neurodegenerative disorders.[1]
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
Physical form
Solution in 50% glycerol containing 0.25 M phosphate buffer, pH 7.5
Other Notes
One unit will hydrolyze 1.0 μmol of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
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Questo articolo | |||
|---|---|---|---|
| specific activity 100-300 units/mg protein (Lowry) | specific activity ≥100 units/mg protein (Lowry) | specific activity ≥100 units/mg protein | specific activity ≥10.0 units/mg protein (modified Warburg-Christian) |
| form buffered aqueous glycerol solution | form buffered aqueous glycerol solution | form lyophilized powder | form ammonium sulfate suspension |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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