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S6069

Sp 5,6-DCl-cBIMPS

Name: Sp 5,6-DCl-cBIMPS
Brand: SIGMA

≥98% (HPLC), solid

Sinonimo/i:

5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3′,5′-cyclic monophosphorothioate, Sp- isomer sodium salt

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About This Item

Formula empirica (notazione di Hill):

C₁₂H₁₀Cl₂N₂O₅PSNa

Numero CAS:

120912-54-1

Peso molecolare:

419.15

Numero MDL:

MFCD06795834

Codice UNSPSC:

12352200

ID PubChem:

24724615

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white

Solubilità

H₂O: 1 mM
DMSO: freely soluble
ethanol: freely soluble

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Stringa SMILE

[Na+].O[C@@H]1[C@@H]2O[P@]([S-])(=O)OC[C@H]2O[C@H]1n3cnc4cc(Cl)c(Cl)cc34

Applicazioni

Sp 5,6-DCl-cBIMPS may be used in cAMP-dependent protein kinase-mediated cell signaling studies.

Azioni biochim/fisiol

Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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To understand the role of protein kinase A (PKA) in the control of ovarian secretory activity, we examined effects of stimulators (db-cAMP, 6-Phe-cAMP, Sp-cDBIMPS) or inhibitors (Rp-cAMPS, KT5720) of PKA on the release of insulin-like growth factor I (IGF-I), progesterone

The human PER1 gene is inducible by interleukin-6.

Dirk Motzkus et al.

Journal of molecular neuroscience : MN, 18(1-2), 105-109 (2002-04-05)

The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the

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William V Holt et al.

Journal of andrology, 23(4), 557-565 (2002-06-18)

Because poorly motile sperm samples can often be stimulated by treatments that increase intracellular levels of cyclic adenosine monophosphate (cAMP), it has been supposed that such samples are unable to maintain an adequate supply of the cyclic nucleotide with which

Urocortin relaxes rat tail arteries by a PKA-mediated reduction of the sensitivity of the contractile apparatus for calcium.

L Lubomirov et al.

British journal of pharmacology, 134(7), 1564-1570 (2001-11-29)

1. Urocortin is an endogenous vasodilator although the mechanism of vasorelaxation is not completely understood. The hypothesis that an alteration of smooth muscle calcium concentration is involved was tested using isometric tension recording and calcium fluorimetry. The relationship between contraction

Effects of protein phosphatase inhibitor calyculin a on the postacrosomal protein serine/threonine phosphorylation state and acrosome reaction in boar spermatozoa incubated with a cAMP analog.

Jun Adachi et al.

The Journal of reproduction and development, 54(3), 171-176 (2008-02-29)

In order to reveal the involvement of the sperm postacrosomal region in the acrosome reaction, we examined the effects of the protein phosphatase inhibitor calyculin A on the postacrosomal protein serine/threonine phosphorylation state and acrosome morphology in boar spermatozoa incubated

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