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S0693

Sigma-Aldrich

SB 204741

>98% (HPLC)

Sinonimo/i:

N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

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10 MG
CHF 205.00
50 MG
CHF 820.00

CHF 205.00

Spedizione prevista il05 aprile 2025

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10 MG
CHF 205.00
50 MG
CHF 820.00

About This Item

Formula empirica (notazione di Hill):
C14H14N4OS
Numero CAS:
152239-46-8
Peso molecolare:
286.35
Numero MDL:
MFCD00923644
Codice UNSPSC:
12352200
ID PubChem:
24278321
NACRES:
NA.77

CHF 205.00

Spedizione prevista il05 aprile 2025

Richiedi un ordine bulk

Livello qualitativo

100

Saggio

>98% (HPLC)

Stato

solid

Colore

off-white to tan

Solubilità

DMSO: soluble >20 mg/mL

Ideatore

GlaxoSmithKline

Temperatura di conservazione

2-8°C

Stringa SMILE

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
USFUFHFQWXDVMH-UHFFFAOYSA-N

Informazioni sul gene

human ... DRD2(1813) , DRD3(1814) , DRD5(1816) , HTR1E(3354) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
rat ... Adra1a(29412) , Gabra2(29706) , Htr1a(24473) , Htr2b(29581) , Htr3a(79246)

Applicazioni

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
  • to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish[1]
  • to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice[2]
  • to test its effect in reducing scratching behavior evoked by sertraline in mice[3]

Azioni biochim/fisiol

5-HT2B serotonin receptor antagonist.
SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.[4]

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Sold for research purposes under agreement from Glaxo­Smith­Kline

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000202536
0000236870
0000236870
0000202536
0000130637

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.
Sang Hoon Lee et al.
The Journal of allergy and clinical immunology, 142(4), 1349-1352 (2018-06-20)
Qiqi Yang et al.
Cellular and molecular gastroenterology and hepatology, 3(3), 484-499 (2017-05-04)
Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than in women. Although sex hormones are believed to play a critical role in this disparity, the possible contribution of other factors largely is unknown. We aimed to investigate the
Ercan Ozdemir et al.
Bioelectromagnetics, 40(5), 319-330 (2019-06-04)
Much evidence demonstrates the antinociceptive effect of magnetic fields (MFs). However, the analgesic action mechanism of the electromagnetic field (EMF) is not exactly understood. The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor
Xiaowei Li et al.
Frontiers in psychiatry, 9, 734-734 (2019-01-23)
The long-lasting loss of sleep is a generally acknowledged risk factor for the occurrence of major depressive disorder (MDD), whereas sleep abnormalities being a key clinic symptom of the MDD. In our previous work, we demonstrated that the sleep deprivation
Annika Gocht et al.
Transplant immunology, 49, 43-53 (2018-04-13)
Cardiac allograft vasculopathy (CAV) is the main obstacle for long-term survival after heart transplantation. Alloimmune mediated chronic vascular rejection results in several mechanisms like platelet activation, immigration of inflammatory cells through the endothelial layer and proliferation and migration of smooth
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