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Merck
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Documenti fondamentali

S0274

Sigma-Aldrich

[D-Arg1, D-Trp7,9, Leu11]-Substance P acetate salt

≥97% (HPLC)

Sinonimo/i:

Spantide I

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About This Item

Formula empirica (notazione di Hill):
C75H108N20O13 · xC2H4O2
Numero CAS:
Peso molecolare:
1497.79 (free base basis)
Codice UNSPSC:
12352200

Saggio

≥97% (HPLC)

Temperatura di conservazione

−20°C

Stringa SMILE

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

Informazioni sul gene

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2

Azioni biochim/fisiol

Potent NK-1 tachykinin receptor antagonist.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Radomir Radomirov et al.
Archives italiennes de biologie, 148(4), 377-388 (2011-02-11)
The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques. Electrical field stimulation
Hiroshi Onimaru et al.
The Journal of physiology, 590(7), 1615-1624 (2012-02-09)
The parafacial respiratory group (pFRG) in the rostral ventrolateral medulla of the newborn rat is predominantly composed of pre-inspiratory (Pre-I) neurons and is involved in respiratory rhythm generation. The subgroup located close to the ventral surface (at least partially overlapping
Qing Lin et al.
Molecular pain, 3, 30-30 (2007-10-27)
Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in
K Folkers et al.
British journal of pharmacology, 83(2), 449-456 (1984-10-01)
Five undeca- and six C-terminal heptapeptide substance P (SP) analogues were tested for their capacity to block the contractile effect of SP on the guinea-pig isolated taenia coli. They had one feature in common, namely substitutions in positions 7 and
P A Cragg et al.
Respiration physiology, 95(3), 295-310 (1994-03-01)
In the present study, we tested the hypothesis that substance P (SP) is an excitatory peptide to the rat carotid body and plays an important role in chemosensory excitation by hypoxia. Chemosensory discharge was recorded from the cut carotid sinus

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