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RAB0707

Sigma-Aldrich

Human LDLR / Low-density Lipoprotein Receptor ELISA Kit

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About This Item

Codice UNSPSC:
41116158
NACRES:
NA.32

Reattività contro le specie

human

Confezionamento

kit of 96 wells (12 strips x 8 wells)

tecniche

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
standard curve range: 8.19-2000 pg/mL

Metodo di rivelazione

colorimetric

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... LDLR(3949)

Descrizione generale

The antibody pair provided in this kit recognizes human Low-density Lipoprotein Receptor.
LDLR (low density lipoprotein receptor) codes for a transmembrane receptor glycoprotein, containing 860 amino acids and is mapped to human chromosome 19p13.2.

Applicazioni

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Azioni biochim/fisiol

LDLR′s (low density lipoprotein receptor) major function is to regulate the level of lipoprotein particles by mediating the clearance of LDL-cholesterol and triglyceride through receptor mediated endocytosis. LDLR is involved in proliferation by providing cholesterol for membrane synthesis. The LDLR gene is a target for treating cardiovascular diseases. Mutation in the gene causes familial hypercholesterolemia.

Altre note

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

I componenti del kit sono disponibili anche separatamente

N° Catalogo
Descrizione
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pittogrammi

Corrosion
GHS05

Avvertenze

Warning

Indicazioni di pericolo

H290

Consigli di prudenza

P234 - P390

Classi di pericolo

Met. Corr. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Mutational screening in the LDLR gene among patients presenting familial hypercholesterolemia in the Southeast of Brazil.
Molfetta G A, et al.
Genetics and molecular research : GMR, 16(3) (2017)
5-Azacytidine engages an IRE1?-EGFR-ERK1/2 signaling pathway that stabilizes the LDL receptor mRNA.
Mnasri N, et al.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1861(1), 29-40 (2018)
Daniel S Hsia et al.
The British journal of nutrition, 124(6), 577-585 (2020-04-18)
Cranberries are high in polyphenols, and epidemiological studies have shown that a high-polyphenol diet may reduce risk factors for diabetes and CVD. The present study aimed to determine if short-term cranberry beverage consumption would improve insulin sensitivity and other cardiovascular
E Soemirien Kasanmoentalib et al.
Journal of neuroinflammation, 16(1), 279-279 (2019-12-31)
The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is a complement regulatory protein inhibiting alternative
Frank Guarnieri et al.
PloS one, 14(12), e0225780-e0225780 (2019-12-06)
PCSK9 is a protein secreted by the liver that binds to the low-density lipoprotein receptor (LDLR), causing LDLR internalization, decreasing the clearance of circulating LDL particles. Mutations in PCSK9 that strengthen its interactions with LDLR result in familial hypercholesterolemia (FH)
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