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RAB0019

Sigma-Aldrich

Human Amphiregulin ELISA Kit

for serum, plasma, cell culture supernatant and urine

Sinonimo/i:

AR

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About This Item

Codice UNSPSC:
41116158
NACRES:
NA.32

Reattività contro le specie

human

Confezionamento

kit of 96 wells (12 strips x 8 wells)

tecniche

ELISA: suitable
capture ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type urine
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/mL
standard curve range: 16.46-4000 pg/mL

Metodo di rivelazione

colorimetric

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... AREG(374)

Descrizione generale

The Human Amphiregulin (AR) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human AR in serum, plasma, cell culture supernatants and urine.
The AREG (amphiregulin) gene codes for a shedding ectodomain, derived from a transmembrane precursor of 252 amino acids. The encoded protein is released into blood or cellular vicinity through autocrine and paracrine. Areg is predominantly expressed in epithelial, mesenchymal cells and also by active immune cells. The AREG gene is mapped to human chromosome 4q13.3.

Immunogeno

Recombinant Human Amphiregulin

Applicazioni

Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human Amphiregulin ELISA Kit has been used to estimate the plasma concentration of amphiregulin by ELISA.

Azioni biochim/fisiol

Areg (amphiregulin) stimulates growth-signaling pathways via EGF (epidermal growth factor) receptors. Areg participates in the organogenesis of mammary gland. It is regarded as a pro-oncogenic factor and contributes to tumor progression. Upregulation of the AREG gene is observed in cancer and resists chemotherapy. AREG reduces E-cadherin expression in order to promote invasion and progression of ovarian cancer.

Altre note

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

I componenti del kit sono disponibili anche separatamente

N° Catalogo
Descrizione
SDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pittogrammi

Corrosion
GHS05

Avvertenze

Warning

Indicazioni di pericolo

H290

Consigli di prudenza

P234 - P390

Classi di pericolo

Met. Corr. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Abnormal amphiregulin expression correlates with gastric cancer prognosis.
Wang B, et al.
Oncotarget, 7(47), 76684-76684 (2016)
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
Cheng J C, et al.
Oncotarget, 7(49), 81645-81645 (2016)
Predictive blood plasma biomarkers for EGFR inhibitor-induced skin rash.
Hichert V, et al.
Oncotarget, 8(21), 35193-35193 (2017)
Correlation between Trop2 and amphiregulin coexpression and overall survival in gastric cancer.
Zhao W, et al.
Cancer Medicine, 6(5), 994-1001 (2017)
Masaru Karakawa et al.
Journal of cellular physiology, 229(12), 1935-1945 (2014-04-09)
The cutaneous T cell-attracting chemokine (CTACK)/CCL27 is indispensable in skin inflammation. CTACK/CCL27 is exclusively produced by epidermal keratinocytes to attract CCR10-expressing T lymphocytes to the skin. We investigated the mechanism of CTACK/CCL27 production from normal human epidermal keratinocytes (NHEKs) by

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