R7907
RON (983-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
CDw136, MST1R, PTK8
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Ricombinante
expressed in baculovirus infected Sf9 cells
Livello qualitativo
Nome Commerciale
PRECISIO® Kinase
Saggio
≥70% (SDS-PAGE)
Forma fisica
buffered aqueous glycerol solution
Attività specifica
69-93 nmol/min·mg
PM
~71 kDa
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... MST1R(4486)
Azioni biochim/fisiol
RON is a macrophage stimulating 1 receptor c-met-related tyrosine kinase. RON receptor tyrosine kinase interacts with HYAL2 receptor protein, rendering it functionally inactive. HYAL2 is a candidate tumor-suppressor glycosylphosphatidylinositol-anchored cell-surface protein that serves as an entry receptor for jaagsiekte sheep retrovirus, a virus that causes contagious lung cancer in sheep that is morphologically similar to human bronchioloalveolar carcinoma. It was shown that RON liberated from the association with HYAL2 becomes functionally active and activates the Akt and mitogen-activated protein kinase pathways.
Stato fisico
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Note legali
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Identification of the ron gene product as the receptor for the human macrophage stimulating protein.
M H Wang et al.
Science (New York, N.Y.), 266(5182), 117-119 (1994-10-07)
Macrophage-stimulating protein (MSP) is a member of the hepatocyte growth factor-scatter factor (HGF-SF) family. Labeled MSP bound to Madin-Darby canine kidney (MDCK) cells transfected with complementary DNA encoding Ron, a cell membrane protein tyrosine kinase. Cross-linking of 125I-labeled MSP to
B Q Li et al.
Biochemical and biophysical research communications, 216(1), 110-118 (1995-11-02)
Macrophage-stimulating protein (MSP) is a chemotactic factor that activates the receptor tyrosine kinase RON. The involvement of Ras in MSP-induced signal transduction was investigated. Here we demonstrate that, in RON-transfected MDCK cells, an active GTP-bound form of Ras was rapidly
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