Q4972

QS11 hydrate

≥98% (HPLC), powder

• Sinonimo/i: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
• Formula empirica (notazione di Hill): C₃₆H₃₃N₅O₂ · xH₂O
• Numero CAS: 944328-88-5
• Peso molecolare: 567.68 (anhydrous basis)
• Numero MDL: MFCD12912439
• Codice UNSPSC: 12352203

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white
• Solubilità: DMSO: >10 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.OC[C@H](Cc1ccccc1)Nc2nc(Oc3ccc4CCCc4c3)nc5n(Cc6ccc(cc6)-c7ccccc7)cnc25

Descrizione

Azioni biochim/fisiol

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)