P8129

5β-Pregnan-3α-ol-20-one

synthetic (organic), ≥98% (TLC), γ-aminobutyric acid A receptors modulator, powder

• Sinonimo/i: 3α-Hydroxy-5β-pregnan-20-one, 3α-Hydroxy-5β-tetrahydroprogesterone, Pregnanolone
• Formula empirica (notazione di Hill): C₂₁H₃₄O₂
• Numero CAS: 128-20-1
• Peso molecolare: 318.49
• UNSPSC Code: 12352202
• PubChem Substance ID: 24898909
• NACRES: NA.77
• MDL number: MFCD00067137
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥98% (TLC)

Proprietà

• Nome del prodotto: 5β-Pregnan-3α-ol-20-one,
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (TLC)
• form: powder
• solubility: chloroform: 50 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H]C12CCC3C4CCC(C(C)=O)C4(C)CCC3C1(C)CC[C@H](O)C2
• InChI: 1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3
• InChI key: AURFZBICLPNKBZ-UHFFFAOYSA-N
• Gene Information: rat ... Gabra2(29706)

Descrizione

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA receptor-mediated currents.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Parola di avvertenza: Warning
• Codici di pericolo: H351
• Avvertenze di sicurezza: P281
• Hazard Classifications: Carc. 2
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges