P7791

Prazosin hydrochloride

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

• Sinonimo/i: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
• Formula empirica (notazione di Hill): C₁₉H₂₁N₅O₄ · HCl
• Numero CAS: 19237-84-4
• Peso molecolare: 419.86
• Beilstein: 4303561
• Numero CE: 242-903-4
• Numero MDL: MFCD00058177
• Codice UNSPSC: 12352200
• ID PubChem: 24277793
• NACRES: NA.77

Proprietà

• product name: Prazosin hydrochloride, ≥99.0% (HPLC)
• Saggio: ≥99.0% (HPLC)
• Forma fisica: powder
• Solubilità: H₂O: 0.5 mg/mL; methanol: 6 mg/mL; dilute aqueous acid: insoluble
• Stringa SMILE: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H; WFXFYZULCQKPIP-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descrizione

Descrizione generale

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Applicazioni

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Azioni biochim/fisiol

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Avvertenza

Hygroscopic; light sensitive.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H336,H361fd,H373
• Consigli di prudenza: P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Classi di pericolo: Repr. 2 - STOT RE 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves