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P7443

Sigma-Aldrich

L-α-fosfatidilcolina

from soybean, ≥99% (TLC), lyophilized powder

Sinonimo/i:

1,2-diacil-sn-glicero-3-fosfocolina, 3-sn-fosfatidilcolina, L-α-lecitina, Azolectina, PC

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100 MG
CHF 287.00
500 MG
CHF 1’010.00
1 G
CHF 1’560.00

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100 MG
CHF 287.00
500 MG
CHF 1’010.00
1 G
CHF 1’560.00

About This Item

Numero CAS:
8002-43-5
Beilstein:
5209585
Numero CE:
232-307-2
Codice UNSPSC:
12352211
NACRES:
NA.25

CHF 287.00

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Origine biologica

soybean

Livello qualitativo

200

Saggio

≥99% (TLC)

Stato

lyophilized powder

Gruppo funzionale

phospholipid

Tipo di lipide

phosphoglycerides

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Stringa SMILE

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
JLPULHDHAOZNQI-ZTIMHPMXSA-N

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Categorie correlate

Descrizione generale

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk.[1] It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes.[2] It is essential for the acetylcholine synthesis functions to nourish the brain.[1] PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD).[3] It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease.[4] PC administration therapy is effective for treating benign symmetric lipomatosis.[5]

Applicazioni

L-α-Phosphatidylcholine has been used:
  • for liposome preparation[6]
  • as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)[7]
  • as a component of serum free substitute for whole blood cells[8]

Azioni biochim/fisiol

Una dei principali fosfolipidi strutturali del cervello, costituisce il 15% circa dei lipidi totali; localizzata soprattutto nella materia grigia.

Confezionamento

Packaged under Argon

Nota sulla preparazione

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000436369
0000436369
0000416190
0000416200
0000416200

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USP

USP

1535733

Fosfatidilcolina

L-α-fosfatidilcolina egg yolk, Type XI-E, 100 mg/mL in chloroform, ≥99%, solution

Sigma-Aldrich

P2772

L-α-fosfatidilcolina

L-α-Phosphatidylcholine, hydrogenated Type I-EH, ≥99%

Sigma-Aldrich

P4139

L-α-Phosphatidylcholine, hydrogenated

L-α-fosfatidilcolina egg yolk, Type XIII-E, 100 mg/mL in ethanol, solution

Sigma-Aldrich

P4279

L-α-fosfatidilcolina

L-α-Lecithin, Egg Yolk, Highly Purified Chromatographically purified.

Sigma-Aldrich

524617

L-α-Lecithin, Egg Yolk, Highly Purified

vibrant-m

Y0001950

Fosfatidilcolina (soia)

Soy PC (95%) Avanti Research™ - A Croda Brand

Avanti

441601G

Soy PC (95%)

Soy PC Avanti Research™ - A Croda Brand

Avanti

840054P

Soy PC

L-α-fosfatidilcolina from dried egg yolk, ≥50% (TLC)

Sigma-Aldrich

61771

L-α-fosfatidilcolina

PERIPHERAL BLOOD PROGENITOR CELLS-Storage of unprocessed G-CSF-mobilized whole blood in a modified Leibovitz's L15 medium preserves clonogenic capacity for at least 7 days
Kreuk AM de, et al.
Bone Marrow Transplantation, 28(2), 145-156 (2001)
The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease
van der Veen JN, et al.
Biochimica et Biophysica Acta - Biomembranes, 1859(9), 1558-1572 (2017)
Christopher B Lee et al.
Plant physiology, 149(2), 791-802 (2008-12-23)
As pollen tubes grow toward the ovary, they are in constant contact with the pistil extracellular matrix (ECM). ECM components are taken up during growth, and some pistil molecules exert their effect inside the pollen tube. For instance, the Nicotiana
Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer?s disease mouse model
Tai YH, et al.
Oncotarget, 9(12), 10681-10681 (2018)
Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients
Chavez-Capilla T, et al.
Journal of environmental sciences (China), 49, 222-232 (2016)
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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