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P6993

Protein Phosphatase 2A1 bovine

≥1500 units/mg protein

Sinonimo/i:

PPA2A1

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Voi/SKUDisponibilitàPrezzo
1 vial
Per conoscere la disponibilità, visualizza il carrello
CHF 824.00

Informazioni su questo articolo

UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD00241719
eCl@ss:
32129103
Specific activity:
≥1500 units/mg protein
Assay:
≥90% (SDS-PAGE)
Biological source:
bovine

CHF 824.00

Per conoscere la disponibilità, visualizza il carrello
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biological source

bovine

Quality Segment

assay

≥90% (SDS-PAGE)

form

solution

specific activity

≥1500 units/mg protein

mol wt

192 kDa

packaging

vial of 1 μg

shipped in

dry ice

storage temp.

−70°C

General description

Protein Phosphatase 2A1 (PP2A1) belongs to the PP2A family and comprises trimeric A, B and C subunits. PPA2 enzymes are serine/threonine phosphatases and exist as several isoforms.

Application

Protein phosphatase 2A1 has been used to treat human fibroblast cells prior to western blot analysis.

Biochem/physiol Actions

Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with microtubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 (PP2A1) binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity. PP2A1 is implicated as a growth suppressor and is associated with dysregulation in cancer. It also regulates cell cycle, RNA splicing differentiation, and signal transduction. PP2A dysfunction is correlated to the tau protein deregulation in Alzheimer′s disease pathophysiology. Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dysregulation in cancer.

Physical form

Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol

Other Notes

One unit will release 1.0 nanomole of phosphate from 32P-labeled phosphorylase A per minute at pH 7.0 at 30 °C.

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Questo articolo
524627539215A3312
Protein Phosphatase 2A1 bovine ≥1500 units/mg protein

Sigma-Aldrich

P6993

Protein Phosphatase 2A1 bovine

Phosphatase Inhibitor Cocktail Set III Phosphatase Inhibitor Cocktail Set III is a ready to use cocktail of four phosphatase inhibitors for broad-spectrum inhibition of both serine/threonine and protein tyrosine phosphatases.

Millipore

524627

Phosphatase Inhibitor Cocktail Set III

Protein C, Human Plasma

Sigma-Aldrich

539215

Protein C, Human Plasma

Anti-Human IgG (γ-chain specific), F(ab′)2 fragment−Alkaline Phosphatase antibody produced in goat affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

A3312

Anti-Human IgG (γ-chain specific), F(ab′)2 fragment−Alkaline Phosphatase antibody produced in goat

description

≥1500 units/mg protein

description

Phosphatase Inhibitor Cocktail Set III is a ready to use cocktail of four phosphatase inhibitors for broad-spectrum inhibition of both serine/threonine and protein tyrosine phosphatases.

description

-

description

affinity isolated antibody, buffered aqueous glycerol solution

biological source

bovine

biological source

-

biological source

-

biological source

goat

specific activity

≥1500 units/mg protein

specific activity

-

specific activity

-

specific activity

-

assay

≥90% (SDS-PAGE)

assay

-

assay

≥95% (SDS-PAGE)

assay

-

form

solution

form

liquid

form

liquid

form

buffered aqueous glycerol solution

shipped in

dry ice

shipped in

wet ice

shipped in

-

shipped in

wet ice

mol wt

192 kDa

mol wt

-

mol wt

-

mol wt

-

Pittogrammi

Exclamation mark
GHS07

Parola di avvertenza

Warning

Codici di pericolo

H317

Hazard Classifications

Skin Sens. 1

Classe di stoccaggio

10 - Combustible liquids

WGK

WGK 2

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

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