P6402

Perphenazine

• Sinonimo/i: 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
• Formula empirica (notazione di Hill): C₂₁H₂₆ClN₃OS
• Numero CAS: 58-39-9
• Peso molecolare: 403.97
• NACRES: NA.77
• PubChem Substance ID: 24278642
• UNSPSC Code: 12352200
• EC Number: 200-381-5
• MDL number: MFCD00056798
• Form: powder

Proprietà

• form: powder
• Quality Segment: 200
• originator: Schering Plough
• storage temp.: 2-8°C
• SMILES string: ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
• InChI: 1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
• InChI key: RGCVKNLCSQQDEP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

Descrizione

General description

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3