P4670

Propafenone hydrochloride

• Sinonimo/i: 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• Formula empirica (notazione di Hill): C₂₁H₂₇NO₃ · HCl
• Numero CAS: 34183-22-7
• Peso molecolare: 377.90
• NACRES: NA.77
• PubChem Substance ID: 24278636
• UNSPSC Code: 41116107
• EC Number: 251-867-9
• MDL number: MFCD00079243
• Form: powder

Proprietà

• form: powder
• Quality Segment: 100
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• InChI key: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• Gene Information: human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Descrizione

General description

Propafenone hydrochloride is a calcium antagonist. It functions as a Na⁺ and K⁺ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

Application

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

Biochem/physiol Actions

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3