P4532

(−)-N⁶-(2-Phenylisopropyl)adenosine

solid

• Sinonimo/i: (R)-N⁶-(1-Methyl-2-phenylethyl)adenosine, N⁶-(L-2-Phenylisopropyl)adenosine, R-(−)-PIA
• Formula empirica (notazione di Hill): C₁₉H₂₃N₅O₄
• Numero CAS: 38594-96-6
• Peso molecolare: 385.42
• NACRES: NA.77
• PubChem Substance ID: 24277681
• UNSPSC Code: 12352200
• EC Number: 254-028-5
• MDL number: MFCD00069194
• Form: solid

Proprietà

• form: solid
• Quality Segment: 200
• potency: 1.17 nM K_i for A₁ receptors (using [³H]CHA in rat forebrain preparations)
• color: white
• solubility: H₂O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)
• storage temp.: 2-8°C
• SMILES string: C[C@H](Cc1ccccc1)Nc2ncnc3n(cnc23)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O
• InChI: 1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1
• InChI key: RIRGCFBBHQEQQH-SSFGXONLSA-N
• Gene Information: human ... ADORA1(134)

Descrizione

Biochem/physiol Actions

A₁ adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)